What is the function of glial fibrillary acidic protein?

GFAP is an intermediate filament protein (Eng et al., 2000) expressed primarily by astrocytes in the CNS. Its main function is to maintain astrocyte structural integrity and aid in cell movement and shape change (Eng et al., 2000).

What is GFAP antibody?

Antibodies to GFAP are very useful as markers of astrocytic cells. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.

Where is glial fibrillary protein?

astroglial cytoskeleton
Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the CNS. This protein is not routinely secreted in blood and is only released after cell death or injury.

What does GFAP stain for?

Immunoperoxidase staining for GFAP produces intense cytoplasmic staining of astrocytes, glial cells, and ependymal cells in normal brain. In neoplastic tissues, GFAP is useful for the identification of glial tumors such as astrocytomas and ependymomas.

What cells are GFAP positive?

GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci. 2006 Apr;31(4):676-84.

What is GFAP in neuroscience?

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes assume a reactive phenotype in acute CNS trauma, ischemia, and in neurodegenerative diseases.

Where is GFAP found?

astrocytes
Glial fibrillary acidic protein (GFAP) is an intermediate filament-III protein uniquely found in astrocytes in the CNS, non-myelinating Schwann cells in the PNS and enteric glial cells.

Are oligodendrocytes GFAP positive?

GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci.

Is GFAP a membrane protein?

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans….Glial fibrillary acidic protein.

What type of protein is GFAP?

The GFAP gene provides instructions for making a protein called glial fibrillary acidic protein. This protein is a member of the intermediate filament family of proteins. Intermediate filaments form networks that provide support and strength to cells.

Are all astrocytomas GFAP positive?

All astrocytoma examined ranged from 5% to 100% of positive cells. GFAP intensity was strong in all cases. Statistics were not performed or mentioned in these studies. n, number of cases.

What is anti-glial fibrillary acidic protein antibody?

Anti-Glial Fibrillary Acidic Protein (GFAP) Antibody is an antibody against Glial Fibrillary Acidic Protein (GFAP) for use in IC, IH, IH (P) with more than 65 product citations. Representative images from a previous lot. A 1:1,000 dilution of a previous lot was used in Immunocytochemistry.

Does anti-glial autoimmunity play a role in IIH?

Recent line of evidence has suggested involvement of inflammation in IIH pathogenesis thus bringing forward anti-glial autoimmunity as a potential contributor of IIH. Glial fibrillary acidic protein (GFAP) is a major astrocytic autoantigen associated with a specific form of meningoencephalitis.

What is GFAP in astrocytes?

GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. Mouse brain tissue, rat astrocytes, rat neurons. Rabbit serum. Liquid. Contains no preservative.