What is oral metronomic chemotherapy?

Hence, metronomic chemotherapy is defined as repeated administration of anti-neoplastic drugs at comparatively low doses frequently and without long drug-free period.

What do chemo numbers mean?

Numbers are often added to the letters to provide additional information about your tumor. In general, the lower the number, the smaller the tumor and the less the cancer has spread. A higher number can mean more advanced cancer.

What is metronomic capecitabine?

Metronomic chemotherapy involves continuous administration of cytostatic drugs at low doses without longer drugfree intervals. Capecitabine (Xeloda) is a prodrug, given in a tablet formulation, that is selectively converted to 5-Fluorouracil at the tumor sites.

At what stage chemotherapy is given?

Metastatic cancer is considered stage IV. Chemotherapy is used to treat advanced-stage breast cancer by destroying or damaging the cancer cells as much as possible. Because chemotherapy medicines affect the entire body, chemotherapy is commonly used to treat advanced-stage breast cancer.

What is metronomic mean?

Definition of metronomic 1 : mechanically regular (as in action or tempo) … the swimmer’s arms lift and glide under the surface in a reliable metronomic cadence …—

How good is capecitabine?

Capecitabine, an oral fluoropyrimidine, has been demonstrated to be at least as effective as bolus 5-fluorouracil/leucovorin in terms of time to disease progression, time to treatment failure, and overall survival, but achieves significantly higher response rates and has the advantage of oral administration.

How does metronomic chemotherapy work in cancer treatment?

MECHANISM OF ACTION Metronomic chemotherapy is a multi-targeted therapy. Metronomic chemotherapy exerts both direct and indirect effects on tumor cells and their microenvironment. It can inhibit tumor angiogenesis, stimulate anticancer immune response and also induces tumor dormancy.

Can metronomic dosing of cytotoxic drugs target tumor angiogenesis in mice?

D. Hanahan, G. Bergers, and E. Bergsland, “Less is, more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice,” The Journal of Clinical Investigation, vol. 105, no. 8, pp. 1045–1047, 2000. View at: Publisher Site | Google Scholar

What is the difference between antiangiogenic and metronomic chemotherapy?

The antiangiogenic drugs directly impair the action of vascular endothelial growth factor (VEGF) and the metronomic chemotherapy disables the cells enrolled in the angiogenic mechanisms, suggesting that the tumoral endothelial cells could be a better target to overcome the drug resistance (Tan et al.).

What is a chemotherapeutic regimen?

Such regimen involves the frequent administration of conventional chemotherapeutic agents at very low doses to target activated endothelial cells in tumors, the advantages of which include minimal adverse effects and a rare chance of developing acquired drug resistance.