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What was the UKPDS study?

by Bobbi Devlin

What was the UKPDS study?

The UK Prospective Diabetes Study (UKPDS) was a landmark randomised, multicentre trial of glycaemic therapies in 5,102 patients with newly diagnosed type 2 diabetes.

When was UKPDS?

Design of UKPDS. The UKPDS was set up in the late 1970s, by Dr Robert Turner and colleagues in Oxford. Over 7600 subjects at 23 centres across the UK were considered for inclusion; 5102 took part. It was the largest and longest study ever undertaken in diabetes; median follow-up was 10 years.

What is Vadt trial?

The primary goal of the Veterans Affairs Diabetes Trial (VADT) was to compare the effects of intensive and standard glucose control on cardiovascular events.

Does metformin have cardiovascular benefit?

Recent studies have also found that metformin has a positive effect on cardiovascular protection [8,9,10,11,12]. Metformin also lowers risk factors for cardiovascular disease such as blood fats [13,14,15], body weight and blood pressure.

What is Advance trial?

ADVANCE (Action in Diabetes and Vascular Disease-PreterAx and DiamicroN Controlled Evaluation) is an ongoing large-scale prospective randomised clinical trial aimed at investigating the effects of blood pressure lowering and intensive blood glucose control in high risk diabetic patients on major macrovascular and …

Is metformin good for blood pressure?

Abstract—Metformin, an antihyperglycemic agent used for treatment of type 2 diabetes mellitus, lowers blood pressure in humans and experimental animals. We recently demonstrated that short-term administration of metformin may lower blood pressure by reducing sympathetic neural outflow.

Can metformin damage your heart?

Several observational and retrospective studies have shown increased mortality and worsening heart failure with the use of metformin (MET). Traditionally, heart failure (HF) was considered a contraindication to its use.

Is metformin a bad drug to take?

Stomach irritation, diarrhea. When starting metformin, around a third of people suffer some degree of stomach irritation, which usually resolves quickly. Only 3 percent to 10 percent of people in clinical trials experience symptoms severe enough that they stop taking the drug.

What are the dangers of metformin?

Lactic acidosis. The most serious,but uncommon,side effect metformin can cause is lactic acidosis.

  • Anemia. Metformin can decrease the levels of vitamin B-12 in your body. In rare cases,this can cause anemia or low levels of red blood cells.
  • Hypoglycemia. Alone,metformin does not cause hypoglycemia or low blood sugar.

    • Why is metformin first line therapy?

    Metformin is the first-line drug of choice to treat patients with type 2 diabetes. It is an oral anti-diabetic drug used with a proper diet and exercise and with other medications when needed to control high blood sugar. It works by helping to restore your body’s proper response to the insulin your pancreas naturally produces.