What is the mechanism of action of nicorandil?

Nicorandil relaxes coronary vascular smooth muscle by stimulating guanylyl cyclase and increasing cyclic GMP (cGMP) levels (as shown first in our laboratory) as well as by a second mechanism resulting in activation of K+ channels and hyperpolarization.

Why nicorandil is contraindicated in left ventricular failure?

Nicorandil is contraindicated in hypotension, left ventricular failure and cardiogenic shock and, as with nitrates, it should not be used with soluble guanylate cyclase stimulators or phosphodiesterase-5 inhibitors due to the risk of severe hypotension.

What class of drug is nicorandil?

Nicorandil belongs to the class of compounds known as potassium channel activators which are characterised by their arterial vasodilator properties. In addition, nicorandil has venodilating properties which are attributable to a nitrate group in its chemical structure.

What is the drug nicorandil used for?

Nicorandil is a medicine used to prevent and treat chest pain caused by angina. Your doctor will usually prescribe nicorandil when other heart medicines have not worked or are not suitable for you.

What is the mode of action of amlodipine?

Mechanism of action Amlodipine is an angioselective calcium channel blocker and inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells which inhibits the contraction of cardiac muscle and vascular smooth muscle cells.

What is the mechanism of action of nifedipine?

Mechanism of Action: The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance.

What is the mechanism of action of ranolazine?

Mechanism of action Ranolazine inhibits persistent or late inward sodium current (INa) in heart muscle in a variety of voltage-gated sodium channels. Inhibiting that current leads to reductions in intracellular calcium levels.

How does nicorandil work?

Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular concentration of cyclic GMP.

How does nicorandil cause hyperpolarization?

Nicorandil more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels to cause hyperpolarization. ATP -NBD1 interaction influences the channel signalling by nicorandil, and the response of the channel to nicorandil is also facilitated and heightened by the interaction of ATP or ADP with NBD2 [A20321].

Is nicorandil an arterial or venous dilator?

Nicorandil is a potassium channel opener with nitrovasodilator (NO donor) actions, making it both an arterial and a venous dilator 11.

How do ATP and NBD1 interact with nicorandil?

ATP-NBD1 interaction influences the channel signalling by nicorandil, and the response of the channel to nicorandil is also facilitated and heightened by the interaction of ATP or ADP with NBD2 3.