Are there any real myostatin inhibitors?

Myostatin is considered an inhibitor of satellite cell activation and as a result skeletal muscle hypertrophy. One promising supplement which has suppressed blood levels of myostatin by 44% is a proprietary bioactive ingredient, Myo-T12, which is follistatin derived from fertile chicken egg yolk isolate.

Are myostatin inhibitors illegal?

Myostatin inhibitors are specifically banned by the World Anti-Doping Agency (WADA).

Is it bad to inhibit myostatin?

Now, a new University of Michigan study in mice suggests that while myostatin inhibitors may indeed bulk up muscles, they may also bring a troubling side effect — small, brittle tendons that could make muscle injuries more likely.

Are myostatin inhibitors safe?

Myostatin inhibitors are relevant as potential therapies for muscle-wasting diseases and muscle weakness in humans and animals. Currently, there are no commercial myostatin inhibitors for agriculture or biomedical purposes because the safest and most effective option has yet to be identified.

Is myostatin an autocrine or paracrine inhibitor?

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, is a critical autocrine/paracrine inhibitor of skeletal muscle growth. Since the first observed double-muscling phenotype was reported in myostatin-null animals, a functional role of myostatin has been demonstrated in the control of skeletal muscle development.

How does myostatin affect bone metabolism?

Myostatin also exerts a significant effect on bone metabolism, as demonstrated by enhanced bone mineral density and bone regeneration in myostatin null mice.

How is myostatin synthesized?

Myostatin is first synthesized as a precursor molecule (pro-myostatin) that undergoes proteolytic processing to produce the biologically active molecule. After removal of the signal peptide (S), pro-myostatin is cleaved by a furin-like protease to form a latent complex, leaving the mature domain (MD) non-covalently attached to the prodomain (PD).

Can myostatin null mice enhance bone mineral density?

Indeed, myostatin null mice represent not only a doubling of muscle mass, but also enhanced bone mineral density (BMD) and bone regeneration [6,8]. The establishment of myostatin as a robust negative regulator of muscle and bone mass has designated myostatin as an attractive therapeutic target for various musculoskeletal disorders.