Can pantoprazole be dissolved in water?

Pantoprazole sodium is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent.

Can pantoprazole be compounded?

Compounded formulations of omeprazole, lansoprazole, and pantoprazole are usually made with sodium bicarbonate. The high pH of sodium bicarbonate protects the active ingredients and improves the stability of the formulation. For pediatric patients, it may be beneficial to add a flavor to the suspension as well.

What is Protonix oral suspension?

What is this medicine? PANTOPRAZOLE (pan TOE pra zole) prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), inflammation of the esophagus, and Zollinger-Ellison syndrome. COMMON BRAND NAME(S): Protonix.

Why pantoprazole is enteric coated?

Because pantoprazole is acid labile, the tablets are enteric coated. An oral liquid dosage form requires the addition of an alkaline ingredient with sufficient acid-neutralizing capacity to facilitate the drug’s safe passage through the stomach.

How do you dilute pantoprazole?

Reconstitute PROTONIX I.V. with 10 mL of 0.9% Sodium Chloride Injection, USP, per vial to a final concentration of approximately 4 mg/mL. Inspect the diluted PROTONIX I.V. solution visually for particular matter and discoloration prior to and during administration.

Can pantoprazole be given subcutaneously?

Conclusions: Pantoprazole given subcutaneously promoted a reduction in gastric acid secretion and was associated with improved healing of the sutured gastric incision in the fundus (squamous epithelium) of rats.

Is there a liquid proton pump inhibitor?

Most PPIs come as pills or capsules, but for patients who have trouble swallowing them, lansoprazole is available as a liquid suspension and Prilosec comes in a powdered formulation.

How do you take liquid omeprazole?

1. This medicine contains 10mg (Omeprazole 2mg/ml Oral Suspension) in each 5 millilitre (5ml) of suspension.
2. Take this medicine by mouth.
3. It is recommended that you take your dose of medicine in the morning.
4. This medicine should be taken on an empty stomach, at least 30 minutes before a meal.

What are the ingredients in pantoprazole?

Each PROTONIX (pantoprazole sodium) Delayed-Release tablet contains 45.1 mg or 22.6 mg of pantoprazole sodium sesquihydrate (equivalent to 40 mg or 20 mg pantoprazole, respectively) with the following inactive ingredients: calcium stearate, crospovidone, hypromellose, iron oxide, mannitol, methacrylic acid copolymer.

What should I eat when taking pantoprazole?

You can eat and drink normally while taking pantoprazole, but it’s best to take it an hour before a meal. It’s best to avoid foods that seem to make your symptoms worse, such as rich, spicy and fatty foods. It also helps to cut down on caffeinated drinks, such as tea, coffee and cola, as well as alcohol.

Can pantoprazole be taken after food?

Pantoprazole can be taken before or after food, although taking it before food is preferable. If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose).

How fast can I push pantoprazole?

PROTONIX I.V. for Injection should be administered intravenously over a period of approximately 15 minutes at a rate of approximately 7 mL/min.

How do you make a suspension of pantoprazole?

A suspension of pantoprazole 2 mg/mL was prepared by triturating 20 40-mg tablets of pantoprazole,a mixing with sterile water for irrigationb and sodium bicarbonate,c and diluting to a final volume of 400 mL with sterile water for irrigation (appendix).

How long does pantoprazole stay in suspension?

The suspension was stable for up to two weeks at 5 °C and up to three months at °20 °C. A suspension of pantoprazole in sodium bicarbonate solution yielded a C max similar to that of the tablet formulation, and the drug was quickly absorbed. However, bioavailability was slightly lower with the suspension than with the tablet.

What is the composition of omeprazole made from?

Compounded formulations of omeprazole, lansoprazole, and pantoprazole are usually made with sodium bicarbonate. The high pH of sodium bicarbonate protects the active ingredients and improves the stability of the formulation. For pediatric patients, it may be beneficial to add a flavor to the suspension as well.

How is pantoprazole administered during fasting in healthy fasting subjects?

In an open-label, randomized, two-period crossover study, healthy fasting subjects received either one enteric-coated 40-mg pantoprazole tablet by mouth with 240 mL of water or 20 mL of a suspension prepared from one crushed pantoprazole tablet and 840 mg of sodium bicarbonate solution and administered via a nasogastric tube.