How common is luf syndrome?

LUF is observed in 10% of natural menstrual cycles in fertile women, but in stimulated cycles it is higher (1). The incidence of LUF has been reported to be 25–43% in infertile women, and the recurrent rate in 2–3 consecutive cycles is 78.6% and 90% respectively (Wang, Qiao, Liu, & Lian, 2008).

What causes a follicle not to rupture?

A follicular cyst can result from failure to ovulate due to excess production of follicle stimulating hormone (FSH) at the time of ovulation. If the follicle does not rupture or release its egg, it instead becomes a cyst.

What is the reason for no dominant follicle?

Some women ovulate irregularly or not at all because their pituitary gland secretes too much prolactin. Higher-than-normal blood levels of prolactin (hyperprolactinemia) inhibit the release of FSH and LH, leading to disruption of development of a dominant follicle and ovulation.

What is Luteinized unruptured follicle syndrome LUFS?

Luteinized unruptured follicular follicle syndrome (LUFS) is a syndrome of failed ovulation in which the follicle does not rupture, despite of the secondary ovulatory changes, such as peak luteinizing hormone (LH), rising progesterone, or endometrial secretion transformation.

Can I get pregnant with luf?

No pregnancies were recorded in patients with LUF during the study period. CONCLUSION: The incidence and recurrence rate of LUF are significantly increased in subsequent cycles of IUI. In these patients, other options of infertility treatment might be justified.

How do you know if you have luf?

Luteinized unruptured follicle syndrome (LUF syndrome). This problem may be detected by correlating the follicle ultrasound results with urinary LH testing.

How is luf syndrome treated?

Therefore, the true magnitude and scope of LUF remains a mystery. Fortunately, this problem is easily resolved by ovulation induction medication and by “triggering” ovulation via an appropriate dose of injectable HCG or gonadotropin-releasing hormone agonist (such as Lupron).

Is it possible to have a dominant follicle and not ovulate?

Luteinized unruptured follicle syndrome occurs when the dominant egg follicle does not rupture. When a woman has regular cycles, in more than 95% of cases it is the sign of regular ovulation. Most tests that are used to confirm ovulation document only the hormonal changes.

How do you tell if you have luf?

LUF was diagnosed if there was no evidence of ovulation after performing four consecutive ultrasonographic examinations. When the patient had more than one follicle on ultrasound, LUF was considered in the absence of any evidence of follicular rupture of all follicles.

How do you fix luf?

What is the prevalence of LUF syndrome in the US?

The luteinized unruptured follicle (LUF) syndrome is estimated to be present in 6–12% of cases of female subfertility. When ovarian stimulation is used the incidence rises to 20–25%. A LUF syndrome tends to return in subsequent cycles.

What is luteinized unruptured follicle (LUF) syndrome?

The luteinized unruptured follicle (LUF) syndrome is estimated to be present in 6–12% of cases of female subfertility. When ovarian stimulation is used the incidence rises to 20–25%. A LUF syndrome tends to return in subsequent cycles. Diagnosis is made by several ultrasound scans starting the day before the expected ovulation.

Is LUF syndrome a cause of infertility?

The only evidence available that the LUF syndrome is a cause of infertility, is the finding that the syndrome occurs statistically more frequently in women with unexplained infertility than in a control group of women.

What is LUFS and why does it matter?

Here’s why: In LUFS, the egg matures and is luteinized, forming a corpus luteum causing an LH surge. The LH surge is detectable in ovulation predictor kits (i.e. OPKs) and as a basal body temperature spike in fertility charting. Fertile cervical mucus may also be present.