Is demeclocycline an ADH antagonist?

Demeclocycline is not a direct antagonist of the vasopressin receptors however, but rather inhibits activation of the intracellular second messenger cascade of this receptor in the kidney by an unknown mechanism.

What is demeclocycline used for?

Demeclocycline is a tetracycline antibiotic. It fights bacteria in the body. Demeclocycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others. Demeclocycline may also be used for purposes not listed in this medication guide.

How does demeclocycline help SIADH?

In conclusion, our in vitro and in vivo data indicate that demeclocycline mainly attenuates hyponatremia in SIADH by reducing adenylate cyclase 5/6 expression and, consequently, cAMP generation, AQP2 gene transcription, and AQP2 abundance in the renal inner medulla, coinciding with a reduced vasopressin escape response …

How does declomycin help SIADH?

Demeclocycline has been used in treatment of the syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH), as it acts on collecting tubule cells to diminish their responsiveness to ADH, in effect essentially inducing nephrogenic diabetes insipidus.

Is demeclocycline used to treat hyponatremia?

Demeclocycline is a bacteriostatic antibiotic of the tetracycline group, which has been shown to cause diuresis and nephrogenic diabetes insipidus (16, 66). Because of the effect on water diuresis, demeclocycline is currently used to treat sustained hyponatremia in patients with SIADH (65, 75, 80).

What is another name for Demeclocycline?

Demeclocycline (INN, BAN, USAN) (brand names Declomycin, Declostatin, Ledermycin, Bioterciclin, Deganol, Deteclo), also known under the brand names Detravis, Meciclin, Mexocine, Clortetrin, is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens.

When was Demeclocycline FDA approved?

Original Approvals or Tentative Approvals

What are Vaptan drugs?

Vasopressin receptor antagonists (Vaptans) are a new group of nonpeptide drugs which have been used in various clinical conditions with limited success. Whereas conivaptan is to be administered intravenously, the other vaptans like tolvaptan, lixivaptan, and satavaptan are effective as oral medication.

What is desmopressin mechanism of action?

By mimicking the actions of endogenous ADH, desmopressin acts as a selective agonist of V2 receptors expressed in the renal collecting duct (CD) to increase water re-absorption and reduce urine production.

How long can you use Demeclocycline?

Demeclocycline is usually given for up to 2 days after symptoms and fever have cleared. Do not share this medicine with another person, even if they have the same symptoms you have. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What is Demeclocycline used to treat?

Demeclocycline is a tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections. A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

What does demeclocycline do to the ribosome?

Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

What should I avoid while taking demeclocycline?

Demeclocycline should not be taken with food (particularly milk and other dairy products) or antacids. As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria.

How does demeclocycline interact with antidiuretic hormone?

Demeclocycline inhibits the renal action of antidiuretic hormone by interfering with the intracellular second messenger cascade (specifically, inhibiting adenylyl cyclase activation) after the hormone binds to vasopressin V2 receptors in the kidney. Exactly how demeclocycline does this has yet to be elucidated, however.