Is NMP banned?

The U.S. Environmental Protection Agency (EPA) describes NMP as a developmental toxicant. In 2017, EPA proposed to ban this chemical’s use in paint stripping but then shelved the proposal under pressure from industry and in 2021 officially withdrew the proposal.

What is NMP and NEP?

This group includes the chemicals N-ethylpyrrolidone (NEP), N-methylpyrrolidone (NMP), and N-isopropylpyrrolidone (NiPP). Alkylpyrrolidones such as NEP are used as chemical reactants, in silicone seal remover, coatings, consumer and commercial paint primer, and adhesives.

What is NMP used for?

N-Methylpyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.

Why is NMP popular?

NMP is a common solvent with extensive industrial uses. Its superior solvent properties, combined with its favorable in vivo tolerability and safety profile, have led to its use as a pharmaceutical excipient in a wide range of current therapies30.

How toxic is NMP?

NMP has a low potential for skin irritation and a moderate potential for eye irritation in rabbits. Repeated daily doses of 450 mg/kg body weight administered to the skin caused painful and severe haemorrhage and eschar formation in rabbits. There is no clear toxicity profile of NMP after multiple administration.

Is NMP hazardous?

Based on the animal tests, you should treat NMP as a potential human reproductive hazard. Overexposure to NMP irritates the eyes, skin, nose, and throat. It can also affect the central nervous system or brain causing symptoms of drunkenness similar to the effects of drinking alcohol.

What is the pH of NMP?

The typical pH of NMP is 8.0 to 9.5. It is a highly polar colorless liquid with a mild amine odor. NMP is a very stable, water-soluble cleaner, with a high flashpoint (196 F [91 C]) and low vapor pressure (0.24 mm Hg/68 F [20 C]).

What is the purpose of NMP in coatings?

NMP helps coatings stick to materials like plastic and other difficult-to-stick-to substrates. When NMP is removed, co-solvents, coalescents or adhesion promoters may need to be used to ensure the same level of adhesion.

What are the benefits of using NMP in the wet phase?

NMP can also aid in substrate wetting, freeze/thaw stability and adhesion to some substrates, as well as acting as a microbicide in the wet phase.

What does NMP stand for?

N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive.

What is the role of NMP in myeloid and endothelial cells?

NMP enhances expression of KLF2 at the transcriptional level by activating the KLF2 promoter. Consequently, NMP displays a consistent range of anti-inflammatory effects upon myeloid and endothelial cells in vitro, opposing TNF-α-mediated inflammatory cytokine production and surface adhesion molecule expression.