What causes Acantholysis?

However, other causes of acantholysis are severe spongiosis (any acute or subacute inflammatory dermatosis), ballooning degeneration (viral infection), proteolytic enzymes released by neutrophils (bacterial and fungal dermatoses), and neoplastic transformation (squamous cell carcinoma, actinic keratosis).

What is skin Acantholysis?

Acantholysis refers to the loss of attachments between keratinocytes, resulting in the formation of rounded, detached cells within the blister. From: Weedon’s Skin Pathology (Third Edition), 2010.

Can herpes cause folliculitis?

Viral folliculitis is a rare disease usually caused by herpes simplex, herpes zoster and molluscum contagiosum in immune-compromised patients.

What is Acantholysis in pemphigus vulgaris?

Specialty. Dermatology. Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. It is absent in bullous pemphigoid, making it useful for differential diagnosis.

Is Grover’s disease curable?

There is no cure for Grover’s disease and treatment is usually based on a person’s symptoms. Affected individuals are usually advised to avoid strenuous exercise and excessive sun exposure, as sweating and heat may induce more itchy spots.

What is focal Acantholysis?

Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis.

Does folliculitis look like herpes?

Folliculitis lesions look and feel almost exactly like herpes lesions, complete with a crust-like surface during the healing process, making them difficult to tell apart at first glance.

How do I know if it’s herpes or folliculitis?

Folliculitis is in the hairy part of the skin while herpes is in areas with thin skin in places transitioning between mucosa and skin. There’s a distinct difference between the thick yellow pus of folliculitis and the thin clear fluid of herpes. This difference is more obvious when the lesion is squeezed.