What color is the glomerulus?

The glomerulus (yellow) is a tuft of tangled capillaries nested inside Bowman’s capsule.

What are the characteristics of the glomerulus?

The glomerulus, the filtering unit of the kidney, is a unique bundle of capillaries lined by delicate fenestrated endothelia, a complex mesh of proteins that serve as the glomerular basement membrane and specialized visceral epithelial cells that form the slit diaphragms between interdigitating foot processes.

What is kidney stain?

Jones’ stain, also Jones stain, is a methenamine silver-Periodic acid-Schiff stain used in pathology. It is also referred to as methenamine PAS which is commonly abbreviated MPAS. It stains for basement membrane and is widely used in the investigation of medical kidney diseases.

What is normal glomerular filtration rate?

A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.

What does the glomerulus look like?

The glomerulus is a loop of capillaries twisted into a ball shape, surrounded by the Bowman’s capsule. This is where ultrafiltration of blood occurs, the first step in urine production. The filtration barrier consists of 3 components: Endothelial cells of glomerular capillaries.

What is the normal glomerular filtration rate?

What collects filtrate from glomerulus?

Bowman’s capsule collects fluid filtered from the glomerulus and serves as a site of entry into the proximal tubule. The glomerulus is a convoluted capillary bed adjacent to Bowman’s capsule. Osmotic and oncotic pressure gradients work to filter the blood from the glomerulus into Bowman’s capsule.

Is GFR 120 normal?

According to the National Kidney Foundation, normal results range from 90 to 120 mL/min/1.73 m2. Older people will have lower than normal GFR levels, because GFR decreases with age.

Why is this normal glomerulus stained with PAS?

This normal glomerulus is stained with PAS to highlight basement membranes of glomerular capillary loops and tubular epithelium. The capillary loops of this normal glomerulus are well-defined and thin. The endothelial cells are seen in capillary loops. The mesangial regions are of normal size.

What is normal glomerulus with H&E stain?

Normal glomerulus, H&E stain. This stain is generally not as useful for evaluating glomeruli, except when thrombi or prominent immune complexes in the form of “wire-loop” or hyaline “thrombi” are present. One mesangial cell is annotated, but it is difficult to distinguish between endothelial and mesangial cells in other areas.

What does normal glomerulus look like?

Normal glomerulus, PAS stain. This normal glomerulus and its annotated cell constituents (endothelial cell, parietal epithelial cell, mesangial cell, podocyte) are highlighted by the periodic acid-Schiff (PAS) stain. The average human glomerulus is up to 200 microns in diameter. Glomerular size is harder to assess without morphometry.

What does Jones methenamine silver stain for glomerulus?

Normal Glomerulus, Jones methenamine silver stain. This stain facilitates visualization of the glomerular basement membranes in this normal glomerulus. If duplication or subepithelial “spike” formation were present, these alterations would be easier to see with this stain compared to the PAS stain.