Common questions

What does a positive immunofixation blood test mean?

What does a positive immunofixation blood test mean?

Positive results from the test indicate the presence of abnormal Ig. This may suggest the existence of an underlying health condition, such as: an immune system disorder. multiple myeloma. Waldenstrom’s macroglobulinemia.

Why would a doctor order an immunofixation test?

This blood test finds out if your body is making or losing protein in abnormal amounts.. It can also tell if you are having problems absorbing protein from foods. This test helps diagnose or check on conditions linked to health problems like the blood cancer multiple myeloma.

What is a normal immunofixation pattern?

Immunofixation can either reveal a normal pattern or identify a monoclonal protein or a polyclonal immunoglobulin pattern. A normal result includes a darker immunoglobulin G (IgG) lane, a lighter immunoglobulin A (IgA), an absent immunoglobulin M (IgM), and a denser kappa compared to lambda lane, with ratio of 2:1.

What does a negative immunofixation blood test mean?

A normal (negative) result means that the blood sample had normal types of immunoglobulins. The level of one immunoglobulin was not higher than any other.

What is the difference between serum protein electrophoresis and immunofixation?

Serum protein electrophoresis (SPEP) is used to determine the type of each protein present and may indicate a characteristic curve (ie, where the spike is observed). Immunofixation is used to identify the subtype of protein (ie, IgA lambda).

Is immunofixation a blood test?

An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. There are two main types of proteins in the blood: albumin and globulin.

How do you read immunofixation results?

What is the difference between SPEP and immunofixation?

In addition, immunofixation technique can also determine the particular isotype of the monoclonal protein. However, immunofixation technique cannot estimate the quantity of the M protein. In contrast, SPEP is capable of estimating the concentration of an M protein.

What is immunofixation electrophoresis used for?

Immunofixation electrophoresis or immunosubtraction electrophoresis can be used to identify abnormal bands seen on protein electrophoresis, typically in the gamma region, in order to determine whether a type of antibody (immunoglobulin) is abnormally produced (e.g., IgG, IgA, IgM).