What does ABCB1 gene do?
What does ABCB1 gene do?
ABCB1 is an environment susceptible gene that codes for P-glycoprotein (P-gp). P-gp is responsible for multidrug resistance during chemotherapy of breast cancer. Six different non-synonymous Single Nucleotide Polymorphism (nsSNPs) of human ABCB1 gene were found in COSMIC database.
Where is ABCB1 found?
In the human genome, 48 different ABC transporters were identified and divided into seven subfamilies A-G based on sequence similarities6. The ABCB1 gene, encoding the P-glycoprotein, is located on chromosome 7q21. 1, consists of 28 introns and 28 exons.
What is MDR1 gene?
The phrase ‘multidrug resistance mutation 1 (MDR1)’ refers to a specific mutation that can occur at a gene known as the MDR1 gene, also known as the ABCB1 gene. Dogs with MDR1 mutations will show negative effects from these drugs at doses that are readily tolerated by dogs without the mutation.
What is ABCG2?
The ABCG2 gene belongs to a group of genes called the ATP-binding cassette family; genes in this family provide instructions for making proteins that transport molecules across cell membranes. In the intestines, the ABCG2 protein helps release (secrete) a substance called urate into the urine.
Do humans have the MDR1 gene?
In humans, there are two MDR genes: MDR1, which is involved in transport of many antitumor agents, and MDR2 which is involved in phospholipid transport.
What is the MDR1 gene in humans?
The human MDR1 gene encodes an integral membrane protein, P glycoprotein (Pgp), whose function is the energy dependent export of substances from the inside of cells, and from membranes, to the outside. Its physiological role is the protection of cells from toxic substances or metabolites.
What dogs carry the MDR1 gene?
A Herding Dog Gene
| BREED | APPROXIMATE FREQUENCY (%) |
|---|---|
| Collie | 70 |
| Long-haired whippet | 65 |
| Australian shepherd | 50 |
| Australian shepherd, mini | 50 |
Where is MDR1 found?
MDR Membrane Proteins MDR1 is found in the gut, kidney, liver, and blood–brain barrier, and mdr1–/– knockout mice have altered ability to withstand and excrete toxic compounds known to be MDR1 substrates.
What are inhibitors of ABCG2 pumps?
Sorafenib is a small molecule shown to inhibit ABCG2 efflux pumps and has also been demonstrated to overcome resistance to chemotherapy in various cancer cells by inhibiting these efflux pumps (Wei et al., 2012; Mazard et al., 2013).
What are BCRP substrates?
BCRP substrates are not limited to chemotherapeutics. Drugs that have been shown to be BCRP substrates include, among others, prazosin, glyburide, cimetidine, sulfasalazine, and rosuvastatin (1,13). Nucleoside and nucleotide analogs such as AZT and lamivudine are also BCRP substrates (1).
What is the use of PGP?
Pretty Good Privacy (PGP) is an encryption program that provides cryptographic privacy and authentication for data communication. PGP is used for signing, encrypting, and decrypting texts, e-mails, files, directories, and whole disk partitions and to increase the security of e-mail communications.
What is the ABCB1 gene?
The membrane-associated protein encoded by the ABCB1 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
What is the function of ABC protein?
ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily.
What does the Cancer Genome Atlas database tell us about ABC proteins?
What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugs. The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells.
Where is abcabcb1 overexpressed?
ABCB1 This gene is overexpressed in Adrenal Gland (x18.3). This gene is overexpressed in Amniocyte (52.1) and Urine (11.3). Tissue specificity: Expressed in liver, kidney, small intestine and brain. This gene was present in the common ancestor of eukaryotes.