What is an axonal neuropathy?

Collapse Section. Giant axonal neuropathy is an inherited condition characterized by abnormally large and dysfunctional axons called giant axons. Axons are specialized extensions of nerve cells (neurons) that transmit nerve impulses.

Can anything be done about neuropathy in the feet?

There is no cure for peripheral neuropathy but proper treatment will slow progression and address your symptoms. If the cause of the foot neuropathy is known, then treatment of the underlying cause may provide relief.

How serious is neuropathy in feet?

If the underlying cause of peripheral neuropathy is not treated, you may be at risk of developing potentially serious complications, such as a foot ulcer that becomes infected. This can lead to gangrene if untreated, and in severe cases may mean the foot has to be amputated.

What causes sudden neuropathy in feet?

Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes and exposure to toxins. One of the most common causes is diabetes. People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling.

Is axonal neuropathy degenerative?

Axonal degenerative polyneuropathies are usually symmetrical, and as the disorder progresses, the axons typically degenerate in a distal-to-proximal gradient. Axonal degeneration is the most common type of pathologic reaction in generalized polyneuropathies, and it is often attributed to a metabolic cause.

Is axonal neuropathy autoimmune disease?

Immune axonal neuropathies are a particular group of immune-mediated neuropathies that occasionally accompany systemic autoimmune rheumatic diseases such as connective tissue dissorders and primary systemic vasculitides.

Is axonal neuropathy a disability?

Neuropathy is considered a disability by the SSA. The SSA refers to a medical guide called the Blue Book when evaluating eligibility for Social Security disability benefits.

What causes axonal neuropathy?

Axonal neuropathy, a characteristic feature of this condition, is caused by damage to a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses.

Is foot deformity present in hereditary peripheral neuropathy?

Abstract. The hereditary peripheral neuropathies are a clinically and genetically heterogeneous group of diseases of the peripheral nervous system. Foot deformities, including the common pes cavus, but also hammer toes and twisting of the ankle, are frequently present in patients with hereditary peripheral neuropathy,…

Can diabetes cause neuropathy foot pain?

In general, peripheral neuropathy, a neuropathy foot pain, can occur for various reasons, including trauma, infections, toxins, genetic disorders, hereditary disorders, or metabolic problems. Diabetes is one of the most common causes of foot pain in neuropathy.

What is the most common foot deformity in high pressure neuropathy?

Foot deformities, including pes cavus, hammer toes, and twisting of the ankle, are commonly present in some HPN forms, such as Charcot–Marie–Tooth (CMT) disease, hereditary neuropathy with predisposition to pressure palsies (HNPP), and distal hereditary motor neuropathy (DHMN) [4], but are uncommon in the other HPN.

Is it common for older adults to have neuropathy in feet?

It can happen at any age, but it is more common among older adults. There are a number of causes for neuropathy occurring in the feet, including: It is estimated that 30 percent of neuropathy cases are idiopathic, or have an unknown cause. In another 30 percent of cases, diabetes is the cause.