What is Malvern method?

The Malvern Mastersizer 3000 is a laser diffraction particle size analyzer, suitable for measuring particle sizes 0.1 um – 3 mm. (Small particles have a small scattering angle, while large particles have a large scattering angle.) Using Mie theory, the data is used to calculate particle size distribution in a sample.

How does the Malvern particle size analyzer work?

How it works. The Mastersizer 3000 uses the technique of laser diffraction to measure the particle size and particle size distribution of materials. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample.

What method determines particle size?

There exists a number of methods of determining particle size of which the most common include sieve analysis, laser diffraction, dynamic light scattering and direct imaging techniques. Frequently, the results of these methods do not correlate well with each other when examining the same samples.

What is the principle behind particle size experiment?

It works on the principle that when a beam of light (a laser) is scattered by a group of particles, the angle of light scattering is inversely proportional to particle size (ie. the smaller the particle size, the larger the angle of light scattering).

What size is a particle?

Particle sizes are measured in microns (μ). A micron is 1/1000 mm. or 1/25,400 in. A millimicron (mμ) is 1/1000 of a micron, or 1/1,000,000 mm. Usually particle size is designated as the average diameter in microns, although some literature reports particle radius.

What are the importance of particle size in a certain formulation?

The particle size can affect the rate a substance will dissolve. Smaller particles have a smaller surface area, therefore making dissolution occur more quickly. The pharmaceutical industry uses this information when designing drugs, as drugs with a smaller surface area will be metabolized more quickly.

Why is particle size important in formulation?

Particle size is a crucial parameter in the pharmaceutical industry, because it influences surface area and porosity and, hence, has an impact on bioavailability, effectiveness and shelf life of a drug. In fact, particle size distribution (PSD) is among the most important parameters to check when evaluating new drugs.

Why particle size is important?

The measurement of particle size is vital to ensuring product bioavailability, efficacy, and shelf life since particle size influences surface area and porosity. A therapeutic’s particle size directly influences its absorption behavior, bioavailability, content uniformity, dissolution, and flowability.

What is the effect of particle size?

The rate of chemical reactions that involve solids depends on the particle size of the solid. A finely powdered solid has a larger surface area than an equal mass of a coarsely powdered solid. A larger surface area is a much easier target for colliding molecules. The bigger the target, the easier it is to hit.