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What is monoclonal B-cell lymphoproliferative disorder?

What is monoclonal B-cell lymphoproliferative disorder?

B-cell lymphoproliferative disorders are conditions in the blood involving uncontrolled growth of lymphocytes (white blood cells). These conditions include such cancers as multiple myeloma, Hodgkin lymphoma and chronic lymphocytic leukemia (CLL), and such precursor conditions as monoclonal B-cell lymphocytosis.

What is CD5 positive B-cell lymphoproliferative disorder?

CD5 positivity in B-cell lymphoproliferative disorders (LPD) is usually considered characteristic of either chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL). However, other neoplastic B-LPDs may express CD5, albeit infrequently.

Which lymphoma is CD5 positive?

CD5 expression is usually seen in chronic lymphocytic leukemia/small lymphocytic lymphoma or mantle cell lymphoma.

What is a monoclonal B-cell?

A condition in which a higher-than-normal number of identical B cells are found in the blood. People with monoclonal B-cell lymphocytosis may develop other B-cell diseases, such as chronic lymphocytic leukemia (CLL). Also called MBL.

Is CD5 B-cell marker?

CD5 is a T cell marker that is not typically expressed on B cells (it is only dimly expressed on a subset of late stage hematogones/normal B-lineage precursors).

Is CD5 at cell marker?

CD5 is a transmembrane glycoprotein that belongs to the conserved scavenger receptor cysteine-rich (SRCR) family of receptors. This family contains extracellular domains homologous to the scavenger receptor type I of macrophages (1). While CD5 is a pan-T cell marker, it is also present on B1a lymphocytes (2, 3).

What is cdcd5 positive B-cell lymphoproliferative disorders?

CD5 positivity in B-cell lymphoproliferative disorders (LPD) is usually considered characteristic of either chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL).

What is the ICD 9 code for lymphocytosis?

Short description: Lymph/hematpoitc tis NEC. ICD-9-CM 238.79is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 238.79should only be used for claims with a date of service on or before September 30, 2015.

What is the pathophysiology of lymphoproliferative disorders?

Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.

Can a definitive diagnosis of CD5+B-CLPD be made with a biopsy?

Conclusions: In patients with CD5+B-CLPD, a definitive diagnosis can be made on an adequate non-BM tissue biopsy suggesting that this entity does not include a novel disease. We recommend that all patients with CD5+B-CLPD should have a non-BM tissue biopsy to make a definitive diagnosis prior to initiation of treatment.