What is the cause of Landau-Kleffner syndrome?

In some cases, Landau-Kleffner syndrome is thought to be caused by mutations (changes) in the GRIN2A gene . This gene provides instructions to the body to make a protein that sends signals to the nerve cells (neurons) in the brain.

What causes temporal lobe epilepsy?

Often, the cause of temporal lobe seizures remains unknown. However, they can be a result of a number of factors, including: Traumatic brain injury. Infections, such as encephalitis or meningitis, or a history of such infections.

What is Landau Kleffner?

What is Landau-Kleffner syndrome? Landau-Kleffner syndrome is a rare language disorder. It often happens in normally developing children, usually between 5 and 7 years of age, and is characterized by the slow or sudden loss of the ability to use or understand spoken language.

What is the difference between Williams syndrome and Down syndrome?

Williams syndrome and Down syndrome are both chromosomal disorders affecting people from birth. However, Williams syndrome is caused by a missing chromosome, while Down syndrome is caused by an extra chromosome.

How do you trigger a temporal lobe seizure?

Causes

1. Traumatic brain injury.
2. Infections, such as encephalitis or meningitis, or a history of such infections.
3. A process that causes scarring (gliosis) in a part of the temporal lobe called the hippocampus.
4. Blood vessel malformations in the brain.
5. Stroke.
6. Brain tumors.
7. Genetic syndromes.

What is Landau-Kleffner syndrome?

Landau-Kleffner syndrome (LKS) is a rare age-related epileptic encephalopathy, characterized by a developmental regression in the area of language, and electroencephalogram (EEG) anomalies located mainly around the temporoparietal areas.

What is the pathophysiology of aphasia LKS?

LKS is an epilepsy syndrome characterized by acquired aphasia and epileptiform EEG abnormalities eventually characterized by ESES. The language disorder could be the result of a paroxysmal disruption of language function during the time of its greatest development and vulnerability .

What is the language disorder of LKS?

The language disorder of LKS has commonalities with autism spectrum disorder. Communication deficits in autism include abnormal development of spoken language and impaired ability to initiate or sustain conversation. The autistic child’s language is often stereotyped, repetitive, and idiosyncratic, with echolalia and neologisms 11.

What is the prognosis of Lennox-Gastaut syndrome (LKS)?

Bishop 4, in an analysis of 119 reported cases up to 1985, argued that the association between age of onset and prognosis suggests LKS is a disorder of higher-level auditory processing. In a younger child without advanced language development, the effect is devastating, as the normal auditory route leading to acquisition of language is blocked.