What is the pH of quinine?

A 27; solution of quinine hydrochloride was found to have a pH of 6.1. dihydrochloride 2.6 and bisulphate 2.4.

Is quinine water soluble?

Quinine is the diastereo isomer of quinidine. It occurs as white, odorless, bulky, bitter crystals, or as a crystalline powder. It darkens when exposed to light and effloresces in dry air. It is freely soluble in alcohol, ether, and chloroform but slightly soluble in water.

What is the MOA of quinine?

Mechanism of Action: Quinine inhibits nucleic acid synthesis, protein synthesis, and glycolysis in Plasmodium falciparum and can bind with hemazoin in parasitized erythrocytes.

What does quinine dissolve in?

Quinine is almost insoluble in water (about 0.05 g per 100 ml water) but it is readily soluble in ethanol. It is alleged that the British Empire-builders took their daily dose of quinine dissolved in ethanol in the form of gin, using lemon or lime to help mask the bitter taste of the quinine.

What is the solubility of quinine in water at room temperature?

Quinine is almost insoluble in water (about 0.05 g per 100 ml water) but it is readily soluble in ethanol.

What is the pH of tonic water?

2.5
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Is quinine polar or non polar?

It has a role as an antimalarial, a muscle relaxant and a non-narcotic analgesic. It is a conjugate base of a quinine(1+)….3.1Computed Properties.

How is quinine metabolized?

Hepatic, over 80% metabolized by the liver. Quinine is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine. Quinine is a documented causative agent of drug induced thrombocytopenia (DIT).

How is quinine extracted from cinchona?

First, the Cinchona bark is extracted under basic conditions (CaO, NaOH) to an organic aromatic solvent (e.g., toluene) at elevated temperatures. Then, it is reextracted with an excess of sulfuric acid to form soluble bisulfates. On partial neutralization and cooling, quinine sulfate is separated.

Is Tonic acidic or alkaline?

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What is the pH of Liquid Plumber?

Drain cleaner (e.g., Drano) usually contains sodium hydroxide (true for both solid and liquid forms). The pH of the liquid ones is likely to be somewhere around 14.

Is quinine an antimalarial?

Quinine is a prescription drug used as an antimalarial drug indicated only for the treatment of uncomplicated Plasmodium falciparum malaria. Quinine sulfate has been shown to be effective in geographical regions where resistance to chloroquine has been documented.

What is the classification of quinine?

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as an antimalarial, a muscle relaxant and a non-narcotic analgesic. It is a conjugate base of a quinine (1+). It derives from a hydride of an (8S)-cinchonan.

What are the side effects of quinine therapy?

Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice. Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.

What is the fluorescence of quinine?

Quinine is a strongly fluorescent compound in dilute acid solution with two excitation wavelengths (250 and 350 nm) and a fluorescence emission at 450 nm. The factors which affect the quantitative determination of quinine (such as concentration quenching and chemical quenching) will be studied as well as the interpretation of the emission spectra.

What is the solubility of drugs at low pH?

This class of drugs favors ionization and adequate solubilization in the stomach at low pH (4). However, reaching the intestinal environment (high pH), drug precipitation may occur due to its lower aqueous solubility (4, 5).