What is the structure of pyrazole?
What is the structure of pyrazole?
Which is the example of pyrazole derivative?
 Many pyrazole derivatives has already found their application as nonsteroidal anti-inflammatory drugs clinically, such as anti-pyrine or phenazone (analgesic and antipyretic), metamizole or dipyrone (analgesic and antipyretic), aminopyrine or aminophenazone (anti-inflammatory, antipyretic, and analgesic).
What are the applications of the pyrazole and its derivatives?
Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc.
What are the uses of pyrazole?
Pyrazole derivatives are used for their analgesic, antipyretic, anti-inflammatory (e.g., antipyrine, phenylbutazone, celecoxib), antibacterial, tranquilizing, anticancer, and antidiabetic activities.
How is pyrazole formed?
Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.
What is the Iupac name of pyrazole?
|Systematic IUPAC name 1,2-Diazacyclopenta-2,4-diene|
|Other names 1,2-Diazole|
Which one is a Pyrazolidinedione derivative?
8.10, the structures of (a) phenazone and derivatives such as propyphenazone and metamizol are given as well as (b) pyrazolidindione derivatives such as phenylbutazone and oxyphenbutazone, which is also metabolite of phenylbutazone.
What type of inhibitor is pyrazole?
Pyrazole and its analogues are widely used to inhibit alcohol dehydrogenase and to block the metabolism of ethanol. Experiments were conducted to demonstrate that pyrazole is oxidized to 4-hydroxypyrazole by isolated rat liver microsomes.
Is pyrazole aromatic or non aromatic?
Pyrazole 1 is an aromatic molecule and, like its structural isomer imidazole, contains a pyrrole-like and a pyridine-like N atom, but in the 1- and 2-positions (1,2-diazole).
What are the properties of pyrazole?
It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C)….Pyrazole.
|Molar mass||68.079 g·mol−1|
|Melting point||66 to 70 °C (151 to 158 °F; 339 to 343 K)|
Why is pyrazole aromatic?
Pyrazole has a five-membered aromatic ring structure containing two vicinal nitrogen atoms, an acidic pyrrole-like nitrogen with a lone pair of electrons involved in aromaticity, a basic sp2-hybridized pyridine-like nitrogen and three carbon atoms (Figure 2) , and these combined features must be carefully taken …
How are novel pyrimidine derivatives synthesized?
A series of novel pyrimidine ( 2, 3 ), pyrazole ( 4, 5 ), and pyridine ( 6) derivatives were synthesized using a chalcone-bearing thiophene nucleus ( 1 ). The target compounds were synthesized by reaction of compound ( 1) with urea, thiourea, malononitrile, hydrazine hydrate, and 2,4-dinitrophenyl hydrazine, respectively.
What is the basicity of pyrazole?
Pyrazole is weaker base (pKa= 2.52), lower basicity is due to extra destabilization of π-bonding after protonation. Pyrazole is very weak acid (pKa=14.21), introduction of electron withdrawing group (-I & -M effect) increase the acidity.
What is the 1h-tautomer of pyrazole?
More… 1H-pyrazole is the 1H-tautomer of pyrazole. It is a conjugate base of a pyrazolium. It is a conjugate acid of a pyrazol-1-ide. It is a tautomer of a 3H-pyrazole and a 4H-pyrazole.
Can pyridones be bioisosteres for phenyls?
Selected literature examples published from the past twenty years where pyridones have been employed as bioisosteres for phenyls, pyridines, pyridine N -oxides and phenol rings are provided. In addition, this review summarizes the current understanding of possible reactive metabolites related to the pyridone structure.