Which proton pump inhibitor can be used with Plavix?

Which proton pump inhibitor can be used with Plavix?

So, which PPIs are safe to use with Plavix? Currently, the manufacturer of Plavix recommends using pantoprazole (Protonix), lansoprazole (Prevacid), or Dexilant (dexlansoprazole). In their research, these three PPIs had the least effect on the effectiveness of Plavix.

Is Plavix a proton pump inhibitor?

The antiplatelet drug clopidogrel (Plavix, and others) reduces major cardiovascular events, but can cause bleeding. Proton pump inhibitors (PPIs) are often used with clopidogrel… The antiplatelet drug clopidogrel (Plavix, and others) reduces major cardiovascular events, but can cause bleeding.

What are the common generic names for proton pump inhibitors?

List of examples of brand and generic names for PPIs

  • omeprazole (Prilosec, Prilosec OTC)
  • aspirin and omeprazole (Yosprala)
  • lansoprazole (Prevacid, Prevacid IV, Prevacid 24-Hour)
  • dexlansoprazole (Dexilent, Dexilent Solutab)
  • rabeprazole (Aciphex, Aciphex Sprinkle)
  • pantoprazole (Protonix)

Can you take omeprazole with Plavix?

FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.

Do proton pump inhibitors reduce the clinical efficacy of clopidogrel?

All PPIs are also metabolised via the cytochrome P450 system, particularly CYP2C19 and CYP3A4. All PPIs inhibit these isoenzymes to different degrees and therefore could affect the clinical efficacy of clopidogrel.

Can you take pantoprazole with blood thinners?

Results of a study presented Monday at the American Heart Association’s annual meeting in Orlando, Fla., also found that people taking the acid reflux drugs Prilosec or Protonix in combination with blood thinners such as Plavix had a higher risk for death after angioplasty than people who didn’t take the two popular …

Can you take Prevacid with Plavix?

Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke. The interaction is most likely to occur if you are using a higher dosage of lansoprazole than recommended or if you are using it too frequently.

Is Plavix blood thinner?

Plavix (clopidogrel) is a cheap, generically available blood thinner that prevents heart attack and stroke.

Is Tagamet a PPI?

Tagamet is a histamine receptor antagonist and Nexium is a proton pump inhibitor (PPI). Both Tagamet and Nexium are available over-the-counter (OTC) and as generics. Side effects of Tagamet and Nexium that are similar include headache, dizziness, drowsiness, diarrhea, nausea, or constipation.

Which proton pump inhibitor works best?

The authors analyzed 41 studies on the effectiveness of PPIs. They concluded that there’s little difference in the effectiveness of PPIs. So, while there’s some data to suggest that esomeprazole is more effective at relieving symptoms, most experts agree that the PPIs have similar effects overall.

What antacid is safe with Plavix?

The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).

Can you take clopidogrel and atorvastatin together?

Talk to your doctor before using atorvastatin and clopidogrel. This combination may reduce the effects of clopidogrel. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity.

Why are proton pump inhibitors (PPI) associated with clopidogrel use?

To prevent gastrointestinal bleeding as a drug-induced side effect, proton pump inhibitors (PPI) are often associated with clopidogrel use. This strategy is recommended by consensus guidelines [ 2] and endorsed by a recent meta-analysis, especially for patients taking dual…

What are the different types of PPIs?

So far, we dispose of five different PPIs on the market: omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole. Each among them is mainly metabolized by the intrahepatic P450 cytochrome system, especially CYP2C19 and CYP3A4, inhibiting them competitively.

Does omeprazole affect platelet function in clopidogrel?

Accordingly, some studies showed that omeprazole attenuates the antiplatelet effect of clopidogrel[13-15] but others did not confirm these findings[19,20]. In contrast, esomeprazole, lansoprazole, pantoprazole and rabeprazole did not affect platelet function in patients treated with clopidogrel[13,15,19-22].