Why does Reglan cause dystonia?

It improves gut movement partly through its antagonistic action on dopamine, which has an inhibitory effect on the gut. However, because it disrupts central dopaminergic signaling, metoclopramide may produce rare movement disorders, such as acute dystonic reactions (Albibi and McCallum, 1983; Bateman et al., 1985).

How does Reglan treat dystonia?

The management of an acute dystonic reaction caused by metoclopramide involves immediate discontinuation of the drug, and rapid administration of intravenous or intramuscular anticholinergics or antihistamines, most often, benztropine, biperiden or diphenhydramine [1, 9, 11, 13].

What medications can cause dystonic reactions?

Neuroleptics (antipsychotics), antiemetics, and antidepressants are the most common causes of drug-induced dystonic reactions. Acute dystonic reactions have been described with every antipsychotic.

What are the adverse effects of Reglan?

Drowsiness, dizziness, tiredness, trouble sleeping, agitation, headache, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Can Reglan cause dystonia?

Metoclopramide can cause severe adverse events, such as an acute dystonic reaction, and should be used with caution in patients with infectious diseases.

What are the symptoms of a dystonic reaction?

Difficulty with vision that affects your eyelids. Difficulty with jaw movement, swallowing or speech. Pain and fatigue, due to constant contraction of your muscles. Depression, anxiety and social withdrawal.

How do you stop a dystonic reaction?

Anticholinergic agents and benzodiazepines are the most commonly used agents to reverse or reduce symptoms in an acute dystonic reaction.

Is a dystonic reaction an emergency?

In rare instances, as with laryngeal involvement, airway management may be necessary. Dystonic reactions are typically not life threatening and result in no long-term effects.

How safe is Reglan during pregnancy?

In summary, this large cohort study shows that exposure to metoclopramide in the first trimester of pregnancy is not associated with significantly increased risks of congenital malformations, low birth weight, or perinatal death.

What causes dystonic reaction?

They reportedly arise from a drug-induced alteration of dopaminergic-cholinergic balance in the nigrostriatum (ie, basal ganglia). Most drugs produce dystonic reactions by nigrostriatal dopamine D2 receptor blockade, which leads to an excess of striatal cholinergic output.

What drugs cause acute dystonia?

Acetophenazine Maleate

How does Benadryl treat dystonia?

Exceptions to this rule include the use of Benadryl to treat acute drug-induced dystonia and the use of dopamine to treat certain forms of inherited dystonia, such as Segawa syndrome. For this reason, all children or adolescents who have dystonia should be given a trial of dopamine.

What is acute dystonia?

Acute Dystonia. Acute dystonia, sometimes called an acute dystonic reaction, can occur within hours or days of exposure to a dopamine blocking drug or, less commonly, after an increased dose of a dopamine blocking drug or decreased dose of a concurrent anticholinergic drug (e.g. benztropine).

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