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How do you give IV aminophylline?

How do you give IV aminophylline?

Add 500mg to 500mL or 250mg to 250mL of a compatible infusion fluid (1mg/mL). Administer using a rate controlled infusion pump. Aminophylline infusions should be continued for at least 24 hours with review by medical staff at agreed intervals, and may be continued for a further 24-48 hours.

What is aminophylline IV used for?

Aminophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting. Aminophylline belongs to a group of medicines known as bronchodilators.

Why do we give aminophylline slowly?

Intravenous Aminophylline must be administered very slowly to prevent dangerous central nervous system and cardiovascular side-effects due to direct stimulating effect of Aminophylline.

Does aminophylline increase heart rate?

Aminophylline increases the heart rate and contractility of a patient. According to clinical studies, Aminophylline or theophylline medication is administered to a COPD patient orally. It enhances both right and left heart systolic pump function.

Can aminophylline be given intramuscular?

This suggests that, although usually not recommended, self-administration of a single dose of aminophylline by i.m. route may temporarily help theophylline-responsive patients in distress, when other routes of administration are not available and facilities for intensive conventional treatment are lacking.

What is the action of aminophylline?

Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.

What is the meaning of aminophylline?

Definition of aminophylline : a theophylline derivative C16H24N10O4 used especially to stimulate the heart in congestive heart failure and to dilate the air passages in respiratory disorders (such as asthma)

What is the mechanism of action of aminophylline?

Aminophylline is a methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly.

Is aminophylline short or long acting?

Short-acting last for 4 to 6 hours. These include Aminophylline, Choledyl, Oxtryphylline. Long-acting last for 12 hours.

What are the contraindications of aminophylline?

Aminophylline contraindications include patients with hypersensitivity to theophylline, ethylenediamine, or any component of the drug formulation….Contraindications

  • Cardiac disease.
  • Renal impairment.
  • Hepatic dysfunction due to any cause.
  • Hypo/hyperthyroidism.
  • Epilepsy.
  • Active peptic ulcer disease[19]

Does aminophylline lower blood pressure?

When both active treatments were combined, the effect on total electromechanical systole, corrected for heart rate, was potentiated (mean decrease -23.3 msec; range -19.1 to -33.1). Neither aminophylline nor the combination affected heart rate or blood pressure, suggesting no increase in myocardial oxygen consumption.

How much aminophylline do you give a newborn baby?

Infants 6 to 52 weeks. 5 to 8 mg/kg (aminophylline or theophylline) IV infused over 30 minutes. In a randomized controlled trial that included 61 premature neonates, a loading dose of 8 mg/kg of aminophylline achieved therapeutic serum concentrations more frequently than 6 mg/kg.

Is aminophylline an alternative to adenosine for FFr testing?

Aminophylline reversal of regadenoson is fast, well-tolerated, and safe. Regadenoson with aminophylline reversal may be considered an alternative to adenosine for FFR measurements, and may have positive implications on the ease and utility of FFR testing.

Is aminophylline a safe reversal agent for regadenoson?

Although aminophylline is a safe and effective reversal agent for regadenoson, most patients would not require reversal given regadenoson’s limited side effect profile.