What is multimerization in biology?

Multimerization is the process of assembling multimers of a given molecule (in this case, an integrase peptide). A multimer is an aggregate of multiple molecules (aka monomers, as mono = one) that is held together with non-covalent bonds.

What is PROTEIN multimerization?

Protein Multimerization. The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.

What does multimerize mean?

1To become converted into a multimer by the linking together of molecules. 2To cause to form a multimer.

What are some of the specific functions of protein Multimerization?

We consider consequences of multimerization on protein enzymatic activity that result directly from interface-interface binding—namely, increased protein stability to degradation, enhanced ligand binding, and catalytic rate.

What is monomeric protein?

A monomer is a molecule that forms the basic unit for polymers, which are the building blocks of proteins. Monomers bind to other monomers to form repeating chain molecules through a process known as polymerization. Monomeric proteins are protein molecules that combine to form multi-protein complexes. …

What is oligomeric protein?

Introduction. Oligomeric proteins, by definition, are composed of more than one subunit (polypeptide chain). As such, they possess a quaternary structure, generally considered to be the highest level of organization within the protein structural hierarchy.

What do dimers do?

For example, dimers form in the cell membrane, where tyrosine-kinase receptors reside, and in the cytosol that contains microtubules composed of tubulin. In the nucleus, hormone receptors, acting as transcription factors, form dimers to increase stability and improve binding to DNA.

What is the highest level of protein structure?

Quaternary (4˚) Structure Quaternary structure in proteins is the most intricate degree of organization still considered a single molecule. To be considered to have quaternary structure, a protein must have two or more peptide chains forming subunits.

Why do proteins dimerize?

Not only can dimerization increase the binding affinity for DNA through cooperativity but, by doubling the length of the DNA site bound by the protein, it can also markedly increase binding specificity. Protein oligomerization is particularly important for the assembly of protein complexes involved in gene expression.

What are monomeric and oligomeric proteins?

Oligomeric proteins, by definition, are composed of more than one subunit (polypeptide chain). However, historically this has not been reflected by depositions in the PDB where monomeric proteins are overrepresented.