What is CD11b marker for?

. CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.

Is CD11b a macrophage marker?

CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. …

What is the difference between CD11b and CD11c?

CD11b is considered a pan-myeloid marker (expressed after granulocyte-monocyte progenitors (GMP) phase in the bone marrow). CD11c is a prefered marker for dendritic cells. But there is exceptions given the variety of tissue distribution of myeloid cells.

What does CD11b stain?

CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen cells and 44% of bone marrow cells. Functionally, CD11b regulates leukocyte adhesion and migration to mediate the inflammatory response.

Do T cells express CD11b?

We have found that CD11b, a cell surface integrin of macrophages, granulocytes, and NK cells, is expressed by a subset of CD8+ T cells that include both the active virus-specific CTL and the virus-specific memory CTL populations. Less than 1% of LCMV-immune splenic lymphocytes expressed CD11b.

Are macrophages CD11b+?

Integrin αM (CD11b) is expressed in myeloid-lineage cells such as monocytes/macrophages, neutrophils, eosinophils, and basophils, and in lymphoid cells such as NK cells and peritoneal B-1 cells (Springer, 1994).

Do monocytes express CD11b?

1999, Thomas et al. 1976, Wiktor-Jedrzejczak and Gordon 1996. Monocytes are defined as blood mononuclear cells with bean-shaped nuclei, expression of CD11b, CD11c, and CD14 in humans and CD11b and F4/80 in mice, and lack of B, T, NK, and DC markers.

What is CD16 a marker for?

CD16 is often used as an additional marker to reliably identify different subsets of human immune cells. Several other CD molecules, such as CD11b and CD33, are traditionally used as markers for human myeloid-derived suppressor cells (MDSCs).

What expresses CD38?

CD38 is expressed in many immune cell types, including bone marrow progenitors, natural killer cells, monocytes, and activated T- and B- lymphocytes [6].

Does B cells express CD11b?

Conclusion: Memory B cells express CD11b and, in contrast with naive B cells, have high migratory ability. CD11b plays an essential role in the homing process of memory cells.

What is the function of CD11b?

CD11b, a marker of macrophages and microglia The CD11 protein is actually a heterodimer complex that consists of CD11b and CD18. CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.

What is the structure of CD11?

The CD11 protein is actually a heterodimer complex that consists of CD11b and CD18. CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.

What is the difference between GR1 and CD11b+ cells?

Hmmm, CD11b is a myeloid marker. Gr1 is an antibody against Ly6G (granulocyte marker) and Ly6C (macrophage marker) – both are of the Ly6 family of GPI anchor proteins. Gr1+/CD11b+ cells are loosely termed myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs)

What is the difference between F4/80+CD11b and CD11c (Hi)?

For tissue specific staining, the resident red-pulp macrophages in the spleen are F4/80+CD11b (lo), but resident macrophages the peritoneal cavity they are F4/80 (hi)CD11b (hi). Conventional dendritic cells (cDC) are CD11c (hi) and Seeing as how you work on MS (so I assume murine EAE), is there a possibility you are looking in the CNS?